The Prado Museum in Madrid hangs a pair of paintings by a seventeenth century painter Juan Carreno de Miranda, paintings of a grossly fat monstrous but innocent five year old girl named Eugenia Martinez Vallejo, called 'La Monstrua vestida' and 'La Monstrua Desnuda': The Monster Clothed and The Monster Naked. They both show an obese five year old girl whose tiny hands and feet and strange shaped eyes and mouth, kinda a suitable freak for a circus. It is plain and obvious that Eugenia showed us symptoms of a rare inherited disease called Prader Willi syndrome. Prader-Willi syndrome children are born floppy, pale skinned, refuse to suck at the breast but eat everything omnivorously, never satisfied at food, and so become grossly obese. Their sex organs are also undevelopped and yet, they are mentally retarded. Unfotunately, like autistic kids they often throw tantrums especially about food.

A family whose descendant has this syndrome usually has an opposite syndrome crop up in their same family tree, called Angelman's syndrome. Founded by Harry Angelman, a doctor from Lancashire called the patients are 'puppet children'. Opposing the Prader Willi symptoms, the children are taut, hyperactive, insomniac, small headed, long jawed and often to stick out their tongues like happy dogs. Their favorite hobbies are to play and laugh but never learn to speak and so severelly retarded.

It soon found that the same chunk of chromosome 15 is missing in the both patients. But the difference is that in Prader Willi syndrom, the missing chunk was from the father's chromosome, while in Angelman's syndrome the missing chunk was from the father's.


Prader Willi syndrome is transmitted through men and vice versa. In summary, we can conclude from both syndromes that, gene remembers which parent it came from because they have paternal or maternal imprint. Thus, the body expresses only the gene that switches on, not both.

Labels: angelman, biology, children, doctor, genes, genetic chromosomes, genome, prader-willi, syndrome

Book Details

Author: Tri Harnoto
Publisher: Galang Press
Year published: 2009
Page number:324
Category: medical
Language text: bahasa Indonesia
Tagline:"Seandainya para dokter mempunyai hati nurani seperti dalam buku ini, niscaya kasus Prita Mulyasari tak akan terulang lagi..."

The Doctor-Catatan Hati Seorang Dokter is a non-fiction medical health book written based on its author experiences, whom is a great doctor that is actually really needed in Indonesia. The author himself is an Indonesian who had abroad to some countries to take higher education. With a bunch of humor senses but keep in a line of medical talking yet, the book is written.

In Indonesia, doctor is a very honored profession. In people's opinion, being doctor is the gate of being rich and yet, it is common to find bias that says, if you a doctor you must be a genius.These opinions sometimes can be said right. Doctor is always needed. People keep sick, there is no time when the whole world are healthy. That's why, doctors keep having their job. But can we accept if the saying, doctors are rich because the medical facilities are getting more expensive?

In this book we can able to perceive the sweet and bitter for being a doctor whose emotion and flawless often neglected by patients and that's why the case of 'a doctor sued by patient'type is not rare. This book will help us for being a good doctor and/or patient by understanding each needs through different eye

Labels: book, doctor, indonesia, medical